Sends a chill down your spine! Really cool how it invokes an unsettling feeling. I know the game you've been inspired by even though I've not played it. Your depiction sends out the same wibes though. I also like the artwork's complexity and simplicity. I could see it printed on a T-shirt, yet it holds up as a desktop background. Really nice.
My only grief with it is that the rimlighting on the hands is a bit too strong on the high-res, makes it look a bit toony. On the image as shown in "normal" resolution on newgrounds that problem isn't there though. Overall though, I don't care since the image is brilliant. Well done :)